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Title: In Vivo PK Library for IVIVE Evaluation
Abstract: We report on new, in vivo TK experiments in rats for 26 chemicals more commonly associated with non-therapeutic and/or unintentional exposure. These chemicals, and an additional 19 chemicals from previously published in vivo rat studies, were systematically analyzed to estimate relevant TK parameters (e.g., volume of distribution, elimination rate). Our analysis created a library of TK parameters for 38 chemicals for which rat-specific in vitro HTTK data were also available. This dataset is associated with the following publication: Wambaugh, J., M. Hughes, C. Ring, D. MacMillan, J. Ford, T. Fennell, S. Black, R. Snyder, N. Sipes, B. Wetmore, J. Westerhout, W. Setzer, R. Pearce, J. Simmons, and R. Thomas. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1): 152-169, (2018).
File Identifier: https://doi.org/10.23719/1390274
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Distribution Title SupplementalTables1-8.docx
Download URL https://pasteur.epa.gov/uploads/A-d7wx/990/SupplementalTables1-8.docx
Download URL https://pasteur.epa.gov/uploads/A-d7wx/990/TableS9-InVivoData-2017-08-10.xlsx
Download URL https://pasteur.epa.gov/uploads/A-d7wx/990/TableS10-PropertiesandEstimates-2017-08-30.xlsx
Download URL https://pasteur.epa.gov/uploads/A-d7wx/990/TableS11-TKSummaryStats-2017-08-30.xlsx
Download URL https://pasteur.epa.gov/uploads/A-d7wx/990/FiguresS1-1compartment-Fittedgeometricmean-2017-08-29.pdf
Download URL https://pasteur.epa.gov/uploads/A-d7wx/990/FiguresS2-2compartment-Fittedgeometricmean-2017-08-29.pdf
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Access Level: Public
License: https://pasteur.epa.gov/license/sciencehub-license.html
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Date Modified: 2017-09-08
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Organization: U.S. EPA Office of Research and Development (ORD)
Contact Person: John Wambaugh
Email: wambaugh.john@epa.gov
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Related Documents: https://doi.org/10.1093/toxsci/kfy020